![]() Saturday, 11 September
spurious factoid proves exceedingly hard to kill
Ever notice how things that "everybody knows" are usually wrong? Here's another one (from here, concerning this paper): It is an established fact that 98 percent of the DNA, or the code of life, is exactly the same between humans and chimpanzees. So the key to what it means to be human resides in that other 2 percent.Argh. Actually, it's an established fact that this meme, or trope, or whatever you want to call it, is bollocks. Individual human genomes vary by about 0.08% at the single-nucleotide level, whereas human and chimpanzee genomes differ by about 1-1.5% at the same level. This is misleading, because single-nucleotide comparison means aligning comparable sequences base-by-base and counting the differences. In order to line up the two sequences in the first place, however, you have to introduce gaps into each sequence to allow for insertions and deletions. Like this: actgccggctaac-----gtaccTgtcaactggcatgcatgcaagtacc actgccggcGaacggtccgtacccgtcaac--gcatgAatgcaagtacc In this made-up example, three bases out of fifty are different (6%) but the gaps account for a further 7 bases' worth of difference (14%). Do this with enough regions of each genome to get a representative sample and you can estimate the degree of sequence identity between the two genomes. Of the optimally-aligned sections of our genomes, we share about 98.5-99% with chimps, but taking the gaps into account produces a rather lower figure of about 95%, something Roy Britten showed in 2002. What both figures overlook, and tend to obscure, is differences in the organization of large sections of the genetic information: duplications, inversions, recombinations between and within chromosomes, insertions of retroviral sequences, and so on. I wrote earlier about a method that allows us to measure such differences. Variation between individual humans on this scale seems to run at about 1.5% (cf. 0.08% at the nucleotide level); it will be interesting to see a ROMA-based comparison between humans and chimps. It is on this organisational scale that the real clues to the inscrutable Decree will be found. ![]() Tuesday, 07 September
Louis MacNeice
Corner Seat Suspended in a moving night Windows between you and the world Museums Museums offer us, running from among the buses, Aubade Having bitten on life like a sharp apple Having felt with fingers that the sky is blue, Not the twilight of the gods but a precise dawn The Sunlight On The Garden The sunlight on the garden Our freedom as free lances The sky was good for flying And not expecting pardon, ![]() Sunday, 05 September
nothing says boredom like pictures of a bike rack...
![]() Sunday, 29 August
amanda and miss noshoulders
![]() Saturday, 28 August
portland light
get that spider out of your pocket
Our friend Mollie is president of the Ozarks Literacy Council, who just had a large and costly window broken by small and worthless scumbags. The intricate iniquities of insurance companies and landlords have conspired to land the council with the full cost of replacement, which they need to raise by Tuesday so as not to conflict with the annual United Way blackout period (whatever that is -- I have no idea, go ask Brad). So, if you have five bucks (or five hundred; hey, you don't know for certain Steve Jobs doesn't read this) to spare, please consider helping out a friend of mine and her worthy cause. ![]() Saturday, 14 August
oregon coast f10w3r pr0n
oregon coast snapshots
![]() Monday, 09 August
portland public and not-so-public art
i'm an alien, i'm a legal alien...
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