Semustine

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Semustine
Systematic (IUPAC) name
N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 13909-09-6
ATC code L01AD03
PubChem CID 5198
UNII 6YY7T1T567 YesY
KEGG D05822 YesY
Chemical data
Formula C10H18ClN3O2 
Mol. mass 247.72 g/mol
 YesY (what is this?)  (verify)

Semustine is a drug used in chemotherapy.[1] It is structurally similar to lomustine, being distinguished from it only by an additional methyl group. It has been taken off the drug market for investigation of its cancerous effects, rated as IARC Group 1 carcinogen or a known carcinogen.[citation needed]

[edit] References

  1. ^ "Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. Gastrointestinal Tumor Study Group". Journal of clinical oncology : official journal of the American Society of Clinical Oncology 10 (4): 549–557. 1992. PMID 1548520.  edit


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