BMJ1y
Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial
Collaborators The CARAT-2 Study Group. The investigators who contributed to CCR1 Antagonist Rheumatoid Arthritis Trial 2 (CARAT-2) are listed in the supplementary appendix, which is provided online ...
gut.bmj23d
Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment
Neutrophils are major players in innate immune system. Here, we aimed to explore the heterogeneity and pro-tumour mechanisms of neutrophils in PDAC. Design We analysed single-cell transcriptomes of ...
BMJ2mon
FRI0337 Tiarp Suppresses Migration of Neutrophils into Joints VIA Down-Regulation of CXCL2/CXCR2 Pathway in Autoimmune Arthritis
Background TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein induced by TNFα and IL-6, and dominantly expressed in macrophages (Mϕ), neutrophils (Neu) and fibroblast-like ...