Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic pathways. FGF21 is expressed in several metabolically active organs and interacts with different tissues. The FGF21 ...

The remaining group of mice, after 4 weeks of high-fat diet (HFD), were injected once with STZ (140 mg/kg) to induce the diabetic nephropathy model. Three of the groups were FGF21 administration ...

Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and ...

Fibroblast growth factor 21 (FGF21) analogs significantly improve fibrosis and resolve metabolic dysfunction-associated steatohepatitis (MASH) without progression, showing promise for non ...

While Fibroblast Growth Factor 21 (FGF21) analogs have shown promise in clinical trials, their underlying molecular mechanisms remain unclear. A research team led by Prof. LI Yu at the Shanghai ...