Frontiers7y
GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg
We found (Tables S7–S9 in Supplementary Material) that systemic lupus erythematosus increases Th2, Th9, Tfh subset genes but decrease Th1 and Treg genes in blood. Th1 cytokine interferon-γ therapy in ...
BMJ3y
Balancing the immune system: Th1 and Th2
vet.uu.nl CD4+ T cells are subdivided into Th1 and Th2 cells. Their relative presence or activation is thought to have a regulatory effect on immune behaviour. Until recently, the relative suppression ...
Frontiers2y
Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells
Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides ...
BMJ10d
Peripheral blood helper T cell profiles and their clinical relevance in MOG-IgG-associated and AQP4-IgG-associated disorders and MS
Methods We measured peripheral blood helper T cell subsets (Th1, Th2, Th17 and regulatory T cell (Treg)) in patients with MOGAD (n=26), AQPAD (n=32) and MS (n=28) in the attack and remission phases by ...
Medscape28d
Inflammation in Pulmonary Arterial Hypertension
Th2 cells, Treg cells, B cells, mast cells Macrophages, T cells, B cells Antiinflammatory, inhibits Th1 response, promotes proliferation and differentiation of Treg cells; promotes differentiation ...
BMJ2mon
Vaccination against AGE-LDL significant attenuates atherosclerosis in diabetic apoE mice
serum cholesterol, triglycerides, and composition of plaque, which could induce specific IgG and IgM against AGE-LDL, upregulate Treg percentage of and IL-10 level in splenocytes supernatant, without ...
gut.bmj9mon
Active ulcerative colitis is associated with downregulation of the TH1, TH2 and TH17 cytokine response and elevated IL-8 levels in mucosal biopsies
There is conflicting evidence from experimental studies on the relative roles of TNFα, IL-8 and cytokines released by Th1, Th2 and Th17 lymphocytes in UC. This may be further complicated by ...
AlphaGalileo11d
Mechanism and application of mesenchymal stem cells and their secreting extracellular vesicles in regulating CD4+T cells in immune diseases
MSCs and EVs demonstrate therapeutic potential in various immune diseases: Systemic Lupus Erythematosus (SLE): MSCs and EVs modulate the balance of Th1, Th2, Th17, Treg, and TFH cells, leading to ...
Medscape3y
Effects of Vitamin D on Immune Disorders With Special Regard to Asthma, COPD and Autoimmune Diseases
VD inhibits the polarization of naive T0 cells to T1 and to a lesser extent T2 cells (5.1.), it shifts the balance of Th1/Th2 T cells toward the latter ones (5.2.) and upregulates Treg cells ...
BMJ1y
AB0564 TIGIT ACTIVATOR ALLEVIATES SYSTEMIC LUPUS ERYTHEMATOSUS BY NEGATIVELY REGULATING TH1-LIKE TREG CELL DIFFERENTIATION
It is reported that the frequency of Th1-like Treg cells, which has low suppressive function, increased in autoimmune diseases [2]. T cells Immunoglobulin and TIMI domain (TIGIT) is a co-inhibitory ...
Nature4y
Examining breastmilk for clues in the fight against food allergies
A newborn’s immune system has more Th2 than Th1 cells. “The infant’s response ... Another population of T cells, called Treg cells, can intervene before the allergic response, fostering ...