Frontiers2y
Canonical NF-κB p65, but Not p105, Contributes to IL-1β-Induced IL-8 Expression in Cardiac Fibroblasts
However, IL-1β failed to induce IL-8 mRNA expression in the cells transfected with p65 small interfering RNA (siRNA), but not in those transfected with p105 siRNA. These observations suggest that ...
Nature4mon
siRNA: brain delivery breakthrough
Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe and non-invasive approach for the delivery of this new ...
GitHub1y
Neurotechnology-at-ETH-Zurich/siRNA_Design
A drawback of Oligowalk is that it has not been updated since 2008. 8. SiRNA Design (IDT) This tool by Integrated DNA Technologies Inc. considers asymmetrical end stability, which is an important ...
Nature19y
siRNA design including secondary structure target site prediction
The double-stranded RNA is processed by an RNase III family enzyme Dicer, resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with ...