Showing posts with label neurotransmitters. Show all posts
Showing posts with label neurotransmitters. Show all posts

Wednesday, January 30, 2019

Your Brain Is Playing Telephone

As a writer, I have observed that my output improves dramatically if I pause now and then to play Solitaire. It is so fruitful that I no longer even worry I'm wasting time, and I just go ahead and play whenever the mood hits.

A typical session might go as follows: black queen on red king, black six on red seven, turn, turn, OMG Camilla needs to be kidnapped and Hattie totally loses her shit in the next scene, three on ace.

It's reliable and cheaper than running a hot shower all day, which is the other way to produce ideas. But I've been at a loss to understand how it works.

In order to understand how creativity works, or any thought process at all, you must know a little about neurotransmission. Fortunately, that's exactly the amount I do know about neurotransmission.

Neurotransmitters are chemicals that poot out of the pointy axon end of a neuron and get gobbled up by the fluffy dendrite end of the next neuron over. It's the way they communicate. Without neurotransmitters, all our cells would just be a jumbled collection jostling each other on the platform, wondering when the train would arrive. But with neurotransmitters, our cells are lined up and whispering to each other in sequence, such that "Take your hand off the burner" eventually arrives in the spinal cord as "Tag Old Stan in the bunghole."

The first named neurotransmitter was discovered in 1921 by a guy named Otto, who got to name it. He called it Vagusstoff, but he was wrong, it turned out to be acetylcholine. Anyway, ol' Otto suspended two beating frog hearts in saline solution and molested one of them, causing it to slow down, and then the other one slowed down too, even though it was not otherwise involved. Also, all the frogs within a ten-mile radius dug deeper down into the mud.

The neurotransmitters in the brain cross over a gap between neurons called a synapse (Greek for "hole in the head"). There are gobs of neurons in the brain, and if you have a very small head like I do, they're packed in really tight. In addition to the neurons, there are even more cells called glia. They are not well understood but appear to be the support crew. They're either tightening bolts or sending out for sandwiches. In addition, they keep the neurons from rubbing up against each other and chafing.

It's not really known if the adult brain continues to create neurons. For a while there it was thought to, because this was observed in rat brains. People were really pumped about that, because they were pretty sure the standard neuron allotment wasn't cutting the mustard. Recently, it's come to light that this might be a rodent thing, and primates more or less make do with what they started with. This would be depressing were it not for the fact that we're already not doing much with the ones we have.

Synaptic pruning in process.
Furthermore, the adult brain is a sleeker model than the child brain, because during adolescence the brain undergoes something called "synaptic pruning," in which some 50% of the neuron connections are tidied up and disposed of. Theoretically this makes the adult brain more streamlined and efficient, but it's possible this is more of a process of civilization for the good of the species as a whole; a process by which humans transition from a life of unbridled masturbation to overeating, TV, and quiet desperation.

Back in oldener times, the brain was thought to be a wired-up electrical model. This was a daunting analysis in the days when people could devote hours to unscrewing every light on the Christmas tree to find the bad bulb. Nowadays we have a more nuanced understanding of brain processes, secure in the notion that if things go wrong we can always unplug, wait a few minutes, and plug back in.

And that's where the Solitaire comes in.

Saturday, August 16, 2014

Brain Frisbees

From Trousering Your Weasel

In our last post, we discussed how marijuana should not be combined with leftover turkey. So how does marijuana work? Well, it goes straight to the brain, because most of the time that's already the highest point in the body, and it travels through the blood-brain barrier. The blood-brain barrier exists in order to allow helpful items like glucose and hormones into the brain's fluid whilst keeping out the little fatties like bacteria and Botulinum that are up to no good. This is why you can inject Botox into your forehead to smooth out wrinkles without worrying about smoothing out the brain also, which you do not want. The active ingredients in marijuana are sleek, and they slither right on in, often illegally, where they wander around before settling down in a few specific areas of the brain: the basal blobular area, the antebellum, and the hippocampus. Fortunately, you're not using most of your brain most of the time. The basal blobular area is only there to keep the rest of the structure from caving in, and the antebellum sits at the back end to provide a cushion during whiplash events. The hippocampus is from the Latin for "the quad where the large animals hang out and play Frisbee," and naturally it's the go-to spot for pot.

The cool guys who were good at tossing a Frisbee could toke on a joint, tuck it under the lip of the Frisbee, and send it to the next guy, and that's sort of what happens in the brain, too. The hippocampus, like the rest of the brain, is lousy with neurons. There are more neurons in the brain than you can count, because you'd fall asleep before you finished. The neurons are single cells but they are not physically connected, and if they want to communicate, they have to throw neurotransmitter chemicals at each other. The pointy end (the axon) of one neuron winds up and tosses the chemical information to the branchy portion (the dendrites) of another. It's all Neurons In Space in there, and the neurons rely on each other's ability to toss and catch to get anything done at all. If the receiving neuron already has its hands full, the doobie of information falls out.

And that's what happens with the pot. The THC in marijuana acts like just another Frisbee and jams the receiving end of the neurons, which gums up their normal functions. Which, in the hippocampus, include your coordination, your short-term memory, and something else. Something-something. I used to know.

So anyway you might look at a pretty red flower and think: oh, wow, that is so red. And a moment later you're still looking at the flower but you think it's the first time you've really looked at it, and you think: oh, wow, that is so red. And so on, and so forth, until soon you are steeped in a redundancy of redness and you will be moved to write a poem about it, a poem without any of the coherence you'd have if you could properly recall your most recent thought. But that won't be clear until you look at the poem later.

And sometimes the fundamental incoherence of your now-compromised neurons starts to set off alarm bells until you're in a full-blown panic about the situation, no long able to track time, with your past disappearing before your eyes and your future, by extension, in doubt. That's what started to happen to me every time I smoked pot, which did not prevent me from continuing to smoke pot. Our generation had a lot invested in the idea that marijuana was harmless, and it took a while for me to consider that it might not be that good for me, personally. In reality, many of us had trouble with panic attacks and paranoia, but we didn't blame the pot. We blamed the Establishment, which was out to get us, a fact we could perceive most clearly when we were stoned.

(Kids are idiots. They'd be better off if they were stashed in the basement at age 13 and not let out until they were 30. Of course, a number of us did spend an equivalent amount of time in the basement, and didn't turn out that well. But it could have been so much worse.)