ERIC MICHAEL JOHNSON
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"If the misery of the poor be caused not by the laws of nature, but by our institutions, great is our sin."
- Charles Darwin
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Showing posts with label mind and brain. Show all posts
Showing posts with label mind and brain. Show all posts

Nov 5, 2007

Encephelon #35

Do you like brains as much as we do?



Image: The Man With Two Brains

Welcome to the 35th installment of the bi-weekly neuroscience blog carnival, Encephelon. You're in for a treat as bloggers from around the globe have put on their thinking caps and related the best of the brains.

Starting us off, Mo from Neurophilosophy has a fascinating (and highly colorful) post on the new technology that allows for multicolored 'brainbows'.

Ed from Not Exactly Rocket Science explains how even crucifixion can’t undermine the neuroscience of optimism. However, broken chains and faulty mirrors cause problems for autistic children.

Robert at Brain Blogger describes a new study showing that anxiety is increased when the immune system detects infection.

Sudip at Brain Blogger shows that finishing high school can help you avoid more than a dead-end job, it can also decrease your likelihood of developing Alzheimer’s disease.

Jake at Pure Pedantry shares his excitement over the new development in brain imaging technology. It involves high-tech photon microscopy with a mouse stuck to a styrofoam ball floating in the air. Following hard on the heels of one technological breakthrough, Jake is back with another in a video that shows a synapse in action.

Sandeep at The Mouse Trap discusses the new study which finds a right brain connection with creative thinking.

PsyBlog discusses the "halo effect" and how politicians and marketing hacks can manipulate you into seeing what they want you to see.

The Neurocritic has three terrific posts on how the brain effects hunger and reinforcement. He also explains how his amygdala is very optimistic but, alas, his subgenual cingulate is sad.

Alvaro at Sharp Brains details Darwin's self-reported lifelong neuroplasticity.

Isabelle at Medopedia discusses why children with Asperger's syndrome have a high incidence of certain sleep disorders.

Ben Hansen reviews the latest book on bipolar children in a piece entitled "Sick Children, or a Sick Society?"

Zachary at Distributed Neuron explains why neurons don't like sweets from the new report in Nature Neuroscience detailing the inhibition of glycogen synthesis in neurons.

Finally, I've included my own piece entitled Monkey See, Monkey Don't Remember about how neurogenesis declines in the aging primate brain.

Noam at Brain in a Vat will be hosting Encephelon #36 on November 19th. Make sure to get your posts in to encephalon{dot}host{at}gmail{dot}com as soon as possible.


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Oct 22, 2007

The Biology of a Mother’s Love

Mother-infant bonds predicted by hormone levels in humans and other mammals



Image: "Mother's Love" by Kolongi Brathwaite

A common tactic by evolution deniers is to claim that if a complex behavior can’t be measured than the scientific method must be a flawed approach towards understanding the world. Nevermind that no one challenges the science of physics just because we can’t predict the complex motions of a leaf in a windstorm. But when it comes to matters of emotion somehow natural explanations are off limits. This is readily apparent in the common argument that, “if you think biology is such a good explanation of behavior, then prove that your mother loves you.” However, as it turns out, we can address this challenge of motherly love and demonstrate a plausible scientific explanation by measuring the levels of the important hormones involved.

Writing in the current issue of Psychological Science (subscription required), Ruth Feldman and colleagues at the Gonda Brain Research Center at Bar-Ilan University in Israel have found evidence that neuroendocrine levels of the hormone oxytocin is a strong predictor of a mother’s bond with her infant. By sampling the blood oxytocin levels of 62 pregnant women (of all educational and employment backgrounds) the researchers found that oxytocin levels remained consistent throughout their pregnancy but differed substantially between the women. By then analyzing video footage of the mothers’ interactions with their infants (which included analysis of how often they gazed at the infant’s face, their amount of affectionate touching, rocking, and how often they spoke in motherese to their child) the researchers found that levels of oxytocin was the major factor in predicting the levels of maternal bonding.

As the authors reported in their study:

The results suggest that the neuroendocrine system associated with bond formation in mammals may play a similar role in humans. OT [oxytocin] was found to be related to a well-defined cluster of maternal behaviors, attachment representations, and a specific maternal behavior that appears across mammalian species . . . These findings lend support to ethological and evolutionary perspectives on human bonding.


Macaque mother with nursing infant.

Image:
Paula Bronstein/Getty Images

In other words, for all mammals there’s evidence that high levels of oxytocin translate into a feeling of personal attachment with their infant. Earlier studies on oxytocin have shown that the hormone is also involved in pair-bonding and cooperative behavior. For example in the closely related prairie and meadow voles, the former is a pair-bonded species that shows high levels of both maternal and paternal care while the latter are neither pair-bonded nor attentive to their offspring. Work carried out by Thomas Insel at Emory University has shown that oxytocin receptor density is the primary difference between the two species.

As to why some individual’s have high oxytocin levels and others don’t is still an open question. Research on primates and rats has shown that daughters who grew up feeling safe and secure with high levels of parental investment demonstrated the same parental behavior with their offspring. It’s likely that a safe and nurturing environment (with both economic and social support for the mother) would increase a mother’s oxytocin levels and could thereby increase the amount of maternal bonding.

However, it’s important to point out that there is not one “optimal” maternal behavior for all environments. Human mothers respond to their surroundings in the same way that other species do. Whether you’re a mouse living in desert landscape or a woman in an impoverished city center, if an environment is particularly harsh it may well be more adaptive for mothers to show less maternal bonding and thereby raise an infant who will be hardened for a difficult life. It’s also important to point out that while these results are highly significant, there is more than just chemistry that influences a mother’s love. We shouldn’t underemphasize the personal decisions or the cultural influences that a woman encounters that influence her maternal behavior. To do so would be to miss the larger picture and not show our full appreciation for the sacrifices that mothers make.

While many interactions are likely to be involved in maternal behavior (both hormonal and social), this study shows that a mother’s love can be partly quantified and predicted using the tools of the scientific method. More than a final retort to my hypothetical interrogator, what this study shows is how remarkably conservative and elegant the products of natural selection can be. To think that a single hormone is identical across mammalian species and can influence one of the most profound feelings imaginable is an awe inspiring thought. To cop a quote from Darwin himself, there truly is “grandeur in this view of life.”

Reference:

Ruth Feldman, Aron Weller, Orna Zagoory-Sharon and Ari Levine (2007). Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychological Science 18(11):965-970. doi:10.1111/j.1467-9280.2007.02010.x


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Oct 16, 2007

Monkey See, Monkey Don't Remember

Neurogenesis declines in the aging primate brain


Marmoset trying to remember if this bug was tasty or not.

Image: Gerald Durell

We’ve all heard that you can’t teach an old marmoset new tricks, but researchers now understand why in a study that hopes to narrow in on the cause of neurodegenerative illness. Writing in the early edition of Proceedings of the National Academy of Sciences, Benedetta Leuner and colleagues at Princeton determined that neurogenesis, or the growth of new neurons, diminishes once these South American monkeys reach sexual maturity. This decline in neurogenesis is particularly noticeable in the hippocampus, a region of the brain central to learning and memory.

This research has been demonstrated previously in rats (I participated in some of this work as an undergraduate student) but there has always been a question as to whether or not the more complex primate brains undergo the same phenomenon:

As the authors reported:

No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. . . These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.

This is why languages are so difficult to learn as an adult while children seem to absorb them readily. Without the growth of new neural connections in the hippocampus the accumulation of information slows dramatically.


Imo, the Japanese macaque who invented potato washing,
a trait that was easily picked up by the young but not older individuals.


Image: Franz de Waal

These results have also been shown in the adoption of new cultural traditions in apes and monkeys. In the famous “potato washing” findings in Japanese macaques, it was younger females who were quickest to learn the new technique while the older males sat around on the periphery wondering what was wrong with the kids these days.

However, the authors point out the situation isn't a hopeless descent from vigorous mental youth to gum-smacking confusion in old age (although Noam Chomsky should be evidence enough of that). As author Elizabeth Gould explains to Science Daily:

"This news isn't entirely negative, though it seems to be at first glance," Gould said. "The silver lining here is that neurogenesis continues long past puberty and does not stop entirely, even in older primates. What's more, it can be stimulated with experience."

So keep keep struggling through Dostoevsky and Foucault. The mental effort will pay off in the long run.

Reference:

Benedetta Leuner, Yevgenia Kozorovitskiy, Charles G. Gross and Elizabeth Gould (2007). Diminished adult neurogenesis in the marmoset brain precedes old age. Proceedings of the National Academy of Sciences, early online edition Oct. 15.


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Sep 10, 2007

His Brain is Gone!

Encephelon #31 is up at Dr. Deborah Serani's Blogspot. Some terrific cognitive and molecular neuroscience reading that is sure to be good brain food.


The Star Trek episode "Spock's Brain" was my first
exposure to the fascinating world of neuroscience.


Be sure to check out:

Neurophilosophy - the neuropsychology of synaesthesia

Cognitive Daily - A new statistic begins to appear in journals: What the heck is a p-rep? (OK, statistics aren't everyone's bag, but since I'm struggling with the subject at the moment I found this to be excellent).

Fitbuff.com - Out of Body Experiences: Medical Mysteries or Scientific Explanation?


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Sep 8, 2007

The Bonding Brain

How the evolution of primate sociality is linked to brain networks for pair bonds.


Social conservatives are fond of linking morality with monogamy and will be quick to condemn the moral crimes of adulterous felatio while ignoring the moral crimes of cutting social programs for poor mothers. However, in a bizarre twist, it seems that morality and monogamy are closely intertwined, though it’s doubtful many conservatives will champion the reasons why.

Those of you who are regular readers of these pages know that I’ve touched on the issues of evolution, cooperation and altruism on several occasions (for example see here and here). In the latest issue of the journal Science, Robin Dunbar revisits this question with a unique perspective on why some species (including humans) succeed so well as members of a group.

While it may come as a shock to the Milton Friedman’s of the world (proponents for the brand of capitalist theory often referred to as “free market fundamentalism”) human beings are a distinctively socialist species. While we come nowhere near the extreme for the natural world (the eusocial bees, ants and termites win the Karl Marx utopian award for selfless behavior on that one) we humans are far and away the most social species of the most social order of the most social class in the animal kingdom (for those of you not up on your Linnaean terminology I refer to primates and mammals respectively). How can I claim such a thing? A very simple measure will suffice: social group size.

Humans have the largest group sizes of any primate. Baboons are known as having the largest group sizes of all non-human primates with an average of about 40-50 individuals and only approach as many as two hundred under extreme circumstances. Humans, in contrast, have an average group size of about 150-200 individuals in hunter-gatherer societies and a maximum group size in the millions under the unique conditions we experience as the result of industrial agriculture. And these large social groups require substantial brain power. All organisms need to successfully predict and navigate their environments and this becomes far more complicated when there are multiple actors interacting in the same social circle.


In the 1990s Robin Dunbar championed an idea known as the Social Brain Hypothesis. He found that mammals who lived in the largest social groups often had the largest neocortex to brain ratio. Since the neocortex is associated with complex and abstract thought he suggested that the demands of group living selected for an increase in neocortex size. In his latest paper in Science he and Susanne Shultz have suggested that there is even more than simply group size that may have influenced this selective process. When the authors analyzed the mating strategies of those highly social mammals that had the largest neocortex they found that pair bonds were significant in all groups except primates.


All social mammals except primates show connection between brain volume and pair bonding

Pair bonds occur when an animal stays with their partner for extended periods rather than simply meet up during the mating season. Pair bonds are cognitively tricky because monogamy is a risky business. In order to avoid getting stuck with a bad partner (either one with bad genes or one who won’t share the costs of reproduction) individuals have to be careful in choosing a good-quality mate. Also, pair bonded individuals have to carefully coordinate their activities to be in synchrony with the other. This may require substantial brain power to predict the other’s behavior and adjust your own behavior accordingly. But why is it significant that the social primates don’t show this connection between a large neocortex and pair bonding like other mammals do? Well, whenever there is a consistent pattern in nature that is violated in a single case a good scientist will want to know why. Primates are already unique among mammals, so any unique qualities that jump out could help us understand the evolution of our lineage.


As mean group size rises so does neocortex ratio

What Dunbar and Shultz have suggested is that the social brain that was selected under conditions for pair bonds in other species has been coopted and utilized for strangers in primate social groups. As the authors state in their paper:
This would explain why, as primatologists have argued for decades, the nature of primate sociality seems to be qualitatively different from that found in most other mammals and birds. The reason is that the everyday relationships of anthropoid primates involve a form of “bondedness” that is only found elsewhere in reproductive pairbonds.
Primates, and humans in particular, are such good social cooperators because we can empathize with others and coordinate our activities to build consensus. Rather than natural selection being a process of selfish individuals maximizing their own fitness, this “bonding brain” hypothesis suggests that natural selection, at least in primates, was a process of maximizing individual fitness through the promotion of the group as a whole. There is already a vast literature on the proximate mechanisms (the hormonal and neurobiological aspects) that promote both pair bonding and affiliative behavior. While there are still many more questions that need to be answered, this research is a promising candidate for understanding the evolutionary origins of primate sociality and human morality itself.


This research doesn’t imply that monogamy causes increased social cooperation, merely that the brain mechanisms selected for in the evolution of pair bonds have been extended to additional members of the primate order. But it’s unfortunate that so many conservatives are adamantly opposed to understanding evolution. Finally a connection between morality and monogamy has been established by Science and their refusal to understand means they'll miss a terrific opportunity to pound the bully pulpit.

Reference:

R.I.M. Dunbar and Susanne Shultz (2007). Evolution in the social brain. Science 317:1344-47. DOI: 10.1126/science.1145463


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Sep 6, 2007

Shamanic Visions of Selective Sweep

The evolution of schizophrenia reveals the nature of contingency


Shaman from the Mbukushu of Namibia

J.B.S. Haldane famously quipped that, if there is a God, he’s inordinately fond of beetles. Others may choose to be somewhat less kind and argue that, with around 2 million species of the beastly little things, such a design could only be the product of a disorganized mind. Perhaps that’s the solution Intelligent Design proponents have been looking for: God is schizophrenic! However, as it turns out, schizophrenia is the perfect metaphor for how our evolutionary history is not a well ordered and implemented design, but is rather full of twists and turns and ill-adapted consequences that are best explained through the contingencies of natural selection.

Several years ago Robert Sapolsky suggested that genes promoting schizophrenia may have been selected for in human evolution because some of them conferred benefits that outweighed the 1% of people worldwide that were disabled by the disorder. Like the sickle-cell trait that confers resistance to malaria (so long as you don’t receive two recessive alleles and develop full fledged sickle cell anemia) a partial schizophrenia may be beneficial in some way. He observed that relatives of schizophrenics have a high likelihood of “schizotypal personalities,” or a mild form of the disorder that just makes these people a little strange and allows them to see the world in a unique way. What if, he wondered, schizophrenia maintained itself in human populations because of selection for schizotypal personalites? As luck would have it, for a hundred years anthropologists had observed such individuals thriving in nearly every society they encountered: shamans.

As Sapolsky stated in 2003 while accepting an award from the Freedom from Religion Foundation:

The critical thing with schizotypal shamanism is, it is not uncontrolled the way it is in the schizophrenic. This is not somebody babbling in tongues all the time in the middle of the hunt. This is someone babbling during the right ceremony. This is not somebody hearing voices all the time, this is somebody hearing voices only at the right point. It's a milder, more controlled version.

Shamans are not evolutionarily unfit. Shamans are not leaving fewer copies of their genes. These are some of the most powerful, honored members of society. This is where the selection is coming from.

Sapolsky hypothesized that the evolution of schizophrenia was ultimately a byproduct of selection for beneficial cognitive adaptations. In the early edition of Proceedings of the Royal Society: Biological Sciences Bernard Crespi, Kyle Summers and Steve Dorus have found that schizophrenia evolved in human populations in just this way. By analyzing specific selective sweeps (or the non-coding regions of DNA that get “pulled along for the ride” when a coding region undergoes a beneficial mutation) they’ve determined that 28 of 76 genes that have been linked to schizophrenia have undergone positive selection during human evolution. These 28 genes are all closely linked to cognitive abilities involved in complex thought.

As the authors summarized their findings:

[G]enetic liability to schizophrenia has evolved as a secondary consequence of selection for human cognitive traits. . . The selective forces underlying adaptive evolution of these genes remain largely unknown, but these findings provide convergent evidence consistent with the hypothesis that schizophrenia represents, in part, a maladaptive by-product of adaptive changes during human evolution.

In other words, the same genes that make us so smart and our species so successful can sometimes (specifically, about 1% of the time) result in a debilitating mental disorder. The other 99% of us are doing so well that these genes continue to perpetuate themselves. In the evolution of complex thought, schizophrenia was accepted as a devil’s bargain.

Whether sexy shamans are the ultimate source for this selection or not remains to be seen. However, what Crespi, Summers, Dorus and Sapolsky have emphasized is that evolution is a messy business and is rarely as straightforward as we might assume. There is no long-term view or plan in the evolutionary narrative. Organisms make do with the raw materials they’re born with and the occasional beneficial mutation simply adds additional supports to a jury rigged foundation. God, if such a being exists, must be inordinately fond of such haphazard construction, his “design” is chock full of them.

Reference:

Bernard Crespi, Kyle Summers and Steve Dorus (2007). Adaptive evolution of genes underlying schizophrenia. Proceedings of the Royal Society: Biological Sciences doi:10.1098/rspb.2007.0876


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Sex for a Handshake

Bonobo research continues despite Congo unrest.


Vanessa Woods and friends

Researchers have gone to the Democratic Republic of Congo to study the social behavior of bonobos -- a close relative of the chimpanzee -- in the Lola ya Bonobo Sanctuary in Kinshasa.

Vanessa Woods, an author and a participant in the study, will be posting daily updates at http://bonobohandshake.blogspot.com.

"We're always comparing ourselves to chimpanzees, but they're only half the picture," said Woods. "Bonobos and chimpanzees are so opposite in many ways, that we really need to understand bonobos if we're ever going to understand ourselves."

Woods and her colleagues from the Max Planck Institute in Germany will look at cooperation, play behavior and altruistic characteristics in the primates.

"A lot of our experiments look silly, like when I throw a bright red soccer ball back and forth, or wave a red porcupine around. But a lot of these games help us understand the way bonobos think. Are they as obsessed with objects as we are? Are they scared of new things?"

Bonobos are smaller than chimps and live in female-dominated societies. They are widely known for the prominent role that sex plays in conflict resolution.

Because the researchers are studying psychology, they can observe bonobos in the unnatural setting of a 35 hectare forest reserve in Kinshasa.

Source: Mongabay.com


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Aug 31, 2007

Bonobo Decides on Names for Swans

An ape is showing researchers just how smart primates can be.



Panbanisha, a bonobo at the Great Ape Trust in Des Moines, has given names to two trumpeter swans nesting at the center. It's an achievement researchers say shows how important collaboration is to learning.

The ape trust focuses on helping primates communicate through computers and symbols.

The latest project began in the spring when the swans were released on the trust's lake. It took months of work to motivate Panbanisha to name the birds.

Researchers made references to the swans while communicating with the bonobo -- showing the ape they were interested in giving them names. They displayed pictures of the swans, played videos of them and took Panbanisha on a walk to find them.

Abstract symbols were developed to help the bonobo distinguish between the three male and female names under final consideration.

And finally this month, Panbanisha made her choices: Morgan and Olivia.

Source: Monkeys in the News



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Aug 27, 2007

Cognitive Science Carnival Today

Encephelon #30, the cognitive science blog carnival is up at Neurofuture. Some of the best science bloggers on the net offer news and analysis about what's on their (and everyone's) mind.

Check it out.

The next edition of Encephalon (make submissions here) is scheduled for September 10th, to be hosted by Dr. Deborah Serani.


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Aug 24, 2007

The Feeling of What Happens

Science, Faith and Nature's Error


The "Revelation" as described by St. John, though likely inspired through the
use of hallucinogens (see The Mystery of Manna).


The title for this post comes from a terrific book by the neuroscientist Antonio Damasio, but I think it's appropriate for a discussion on faith, feeling and reason. Sam Harris' recent editorial in the journal Nature has effectively gotten people talking about religion, science and what, if anything, each should have to do with the other. In a recent discussion with a fellow blogger it was argued that Harris' inclusion of Christian geneticist Francis Collins in his critique of Nature's editorial staff was improper, effectively undermining his argument.

[R]ather than challenge Collins directly, he lumps Collins with Islamic fundamentalists and the Catholic Church as part of a giant "force of unreason" based on views and positions that Collins adamantly opposes. Sounds rather weak to me.

Firstly, while I'm sure there is much that my friend and I could agree upon, I'm afraid that the issue of religion is one area where we significantly differ. Also, it should be noted, Harris said nothing about "Islamic fundamentalists" but was instead criticizing an earlier argument that claimed moderate Islam constitutes an "intrinsically rational world view." In this way he's only comparing moderate Christianity (via Collins) to moderate Islam. I hope we can both agree on that much.

However, whether the issue is Collins' defense of Christianity, a scientific defense of Islam, or an argument from the Pope or President Bush in defense of their religious views, it is all the same issue. They have already come to their conclusions and are simply fitting the facts to their beliefs. They feel the truth of their convictions and that, as they say, is that. Christianity and Islam may indeed represent an "intrinsically rational world view," but only if you accept the premises they are based upon. It therefore comes down to the evidence for or against this initial premise that forms the foundation for everything that follows. Islam is no different than Christianity or Hinduism or Scientology in the sense that it relies upon a revered text (or texts) and the word of authority instead of evidence. Perhaps more importantly, it relies upon a feeling in its believers. But one can feel something powerfully and it can have no basis in reality. It doesn't matter whether one person feels it or a million people feel it. It doesn't make a false reality any more true.



An example would be phantom limbs. A common experience of amputees is to still feel their missing arm or leg years after their accident. They can feel the sensation of opening and closing their hand but, when they open their eyes nothing exists. Their phantom leg will try to get out of bed and pull the frightened person along with them only to bring them crashing to the floor (this is a true case reported to Dr. V.S. Ramachandran in his book Phantoms in the Brain). One could make the argument that a spiritual limb still exists even after the physical limb has been lost. If you accept the premise that we are spiritual beings animating the physical world this is actually a fairly logical conclusion. However, the reality is that this phenomenon is the result of neurons in the somatosensory cortex for that limb which continue to fire and thus create the sensation of a false reality.

It's not too much of a stretch to link such phantom limbs with a feeling for God. What's more likely? That an invisible world exists that controls our destiny (but that people around the globe interpret in vastly different ways) or that all humans have similar neural networks that, under certain circumstances, engender a feeling of the divine? A great deal of work has been done in just this area. A terrific book in this field is Why God Won't Go Away. Among other fascinating discoveries, it demonstrates how Buddhist monks and Franciscan nuns both invoke the same brain regions when they tap into the "oneness of the Universe" or "make contact with God" depending on their various interpretations of the same experience. Through their training and dedication in meditation or prayer they in effect "trick" their mind into creating a false reality.

Other individuals, such as those with temporal lobe epilepsy, have these false realities thrust upon them. Just like epilepsy of the motor cortex that results in spasmodic activation of the muscles, temporal lobe epilepsy causes the same repetitive firing of neuronal circuits but in a region of the brain central for our concept of space and time. Such individuals report ecstatic experiences of being in touch with the divine, or of receiving God's revelation if they were previously religious.


Artist depiction of Ellen G. White experiencing a vision.

To give just one well documented case, Ellen G. White, the founder of the Seventh-day Adventist Church, experienced powerful visions of "revelation" for most of her adult life following a serious head injury. As she described in her voluminous writings:

"I would say that when the Lord sees fit to give a vision, I am taken into the presence of Jesus and the angels, and am entirely lost to earthly things. I can see no farther than the angel directs me. My attention is often directed to scenes transpiring upon earth.

At times I am carried far ahead into the future and shown what is to take place. Then again I am shown things as they have occurred in the past."

Dr. Molleurus Couperus argued, in a study later published in Adventist Times, that the most likely explanation is that these visions were the result of partial-complex seizures such as would occur in temporal lobe epilepsy.

1. Ellen was a healthy normal girl, both physically and emotionally, until at the age of nine, she was hit by a stone on the nasal area of her face. She was unconscious for 3 weeks, indicating a severe brain injury; and was not able to remember anything about the accident or its aftermath. The type and location of her head injury, and the resulting period of unconsciousness and amnesia, made it likely that she would ultimately develop epileptic seizures.

2. Her dreams and visions began at age fifteen, some six years after her accident; and they continued throughout her life. When Ellen's vision experiences are compared with the seizures of temporal lobe epilepsy, they are found to be typical of partial complex seizures.

3. Following this, her behavioral traits were compared with those of temporal lobe epileptics and found to be similar.

Ellen White's visions were no more outlandish than those of past mystics (in fact, epilepsy is a likely candidate for the visions of Muhammad). The only difference is that her experiences and behavior were well documented and can be carefully compared to current neurological case studies. A further argument in favor of the view that the divine is an internal state is that people in cultures all over the world shock their systems through fasting, rhythmic prayer, chanting or even with hallucinogens in order to trick their brains into a mystical experience.



Most people aren't dedicated enough to train their neural pathways such as monks or nuns nor are they afflicted with what could be viewed as either the blessing or curse of temporal lobe epilepsy. But most people are raised in a tradition initiated by others who swear that their internal fantasy must be everyone's reality. Moses, Muhammad, Jesus, Siddhartha, Martin Luther, Joseph Smith, Ellen White, A.C. Bhaktivedanta Swami Prabhupada and many other religious figureheads, both real and mythical, reported fantastic visions not available to most of us (though there is good evidence that Joseph Smith was merely a con man). We believe their visions because, well, we prefer to. It gives us hope. Provides meaning. We don't have to pay attention during biology class. Plus there are hundreds, sometimes thousands, sometimes millions of others that also believe in their visions. Charismatic authority figures spend their lives devoted to spreading these visions to others -- even those who never experienced such visions themselves but always longed to find that same connection. However, all of this just reinforces what is ultimately nothing more than someone's feeling.

So regardless of Francis Collins' credentials as a good scientist (and I wouldn't doubt his ability for a moment) his logic that God exists is based purely on rationalizing a feeling he once had in front of a winter waterfall. Cloaking this feeling in the language of science doesn't give it any more legitimacy, in fact it often led to tangled logic. Collins can believe whatever he likes about his experience, as can anyone. We all live with our private fantasies to a certain extent. However Harris' point is that in the admirable attempt to be inclusive, Nature's editors were foregoing their primary role as skeptical inquirers of sound science. Should they favorably review the next book on astrology if it also includes a reasonably good description of cosmic evolution? I think the point Harris makes is a good one and something we should seriously consider as scientists and citizens. We've seen how effectively faith has led the way in foreign policy decisions. Perhaps a return to reasonable arguments based on solid evidence would be a wiser course for the future.


For a background of my personal experience with religious belief see my post Calculating Faith.


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May 1, 2002

The Biology Of . . . Humor

Reprinted from DISCOVER
Vol. 23 No. 5 (May 2002)
http://discovermagazine.com/2002/may/featbiology

One winter morning
in 1931, at a cemetery in London, Willy Anderson solemnly bowed his head and watched his mother's casket descend into the earth. Suddenly, and to the collective horror of those in attendance, he began to laugh. The outburst was muffled at first, as Anderson desperately covered his mouth, but it soon grew so intense that he had to leave the grave. Hours later, when Anderson still couldn't contain himself, his family took him to a hospital emergency room. The attending doctor checked his pupils and vital signs and could find nothing wrong but recommended that the patient be kept for observation. Two days later, Anderson died. The postmortem revealed that a large aneurysm in an artery at the base of his brain had ruptured, compressing part of his hypothalamus and other adjacent structures.

The science of comedy is rooted in such tragedies. For centuries, thinkers from Aristotle to Darwin tried to discern the nature and origins of humor, only to have their ideas trail off without a punch line. But studies of brain-damaged patients like Willy Anderson (his real name is unknown; the medical literature mentions only this pseudonym) have recently been bolstered by sophisticated brain scans of living subjects. Humor researchers, after decades of study—and some ridicule from their colleagues—have zeroed in on the brain's laughter circuit at last.

Humans are the only creatures that crack jokes, but lots of animals like to laugh. In his 1872 treatise, The Expression of the Emotions in Man and Animals, Charles Darwin pointed out that "very many kinds of monkeys, when pleased, utter a reiterated sound, clearly analogous to our laughter." Since then, studies have found funny bones in any number of beasts—even laboratory rats, which don't have much to laugh about. In a study published two years ago in the journal Behavioral Brain Research, rats responded with playful nips and ultrasonic chirps when psychologists tickled their ribs and bellies. The rats that chirped loudest were also the most eager to be tickled. More interesting, when these ticklish rats were interbred for four generations, the offspring chirped twice as often as their great-grandparents.

Whether or not there are genes for laughter or ticklishness, a true sense of humor involves more than sensitive ribs. At the Institute of Neurology in London, neuropsychologists Vinod Goel and Raymond Dolan describe successful jokes as "a cognitive juxtaposition of mental sets, followed by an affective feeling of amusement." Thankfully, that definition, though mildly humorous in its way, can be subdivided into three more familiar categories: Phonological jokes, or puns ("Why did the golfer wear two sets of pants? He got a hole in one"); semantic jokes that go beyond wordplay ("What do engineers use for birth control? Their personalities"); and nonverbal jokes such as cartoons and slapstick. Each kind of joke draws on a series of mental capacities—each located in a different part of the brain—that seem to set off one another like tumbling dominoes.

Just where all these capacities collide began to become clear in the 1970s and 1980s. Neurologists had long suspected that the right hemisphere was the seat of emotion, personality, and nonliteral language. But when they tested to see if certain language disorders were due to damage to that hemisphere, they made an interesting discovery: The same patients also tended to have poor senses of humor. They would laugh at slapstick, but they had trouble grasping written jokes, and when given a choice of captions for a cartoon, they would often pick the wrong punch line.

To tighten the focus on those early findings, psychologists Prathiba Shammi and Donald Stuss conducted a follow-up study at the University of Toronto. They began by testing the reactions of a group of control subjects to a series of verbal and nonverbal jokes. They then took the jokes that most subjects had rated as "unambiguously humorous" and showed them to 21 patients, each of whom, as an adult, had suffered damage in a different part of their frontal lobes. The results, published in the journal Brain in 1999, were as unambiguous as the jokes: Patients who had damaged right frontal lobes had the worst senses of humor. "There was no problem in simple logic," the psychologists wrote. "When required to provide a logical conclusion to a non-humorous story, they correctly selected the logical ending." But when asked to finish a funny story, these patients tended to choose surprise, slapstick punch lines—even if the story required something quite different. Humor, they assumed, was all about the element of surprise.

One joke, for instance, began with "the neighborhood borrower" approaching his neighbor Mr. Smith. "Say, Smith," he asked, "are you using your lawnmower this afternoon?" "Yes, I am," Smith replied warily. For the borrower's answer, the study subjects were given a choice of the following: (a) "Oops!" as the rake he walked on barely missed his face; (b) "Fine, then you won't be wanting your golf clubs—I'll just borrow them"; (c) "Oh well, can I borrow it when you're done, then?" or (d) "The birds are always eating my grass seed." Control subjects, and those who had a damaged left or back side of the brain, knew the correct answer was (b). But those who had a damaged right frontal lobe usually answered (a). Even when the latter group understood a joke, they often failed to smile or laugh at it.

In their summary of the study, Stuss and Shammi point out that the right frontal lobe has long been considered "the most silent of brain areas." But their findings suggest it may instead be a kind of cerebral clearinghouse, a place where all the components of self-awareness—memory, logic, language, sensation, and emotion—come together. Understanding humor is a serious business, Stuss says. "You need the ability to make an inference; you also need the ability to have a self-awareness concept. Then you need the connectivity to your emotional reactions. The right frontal lobe has the ability, because of its connectivity to different brain regions, to actually pull that all together."

Stuss and Shammi's most humorless patients had a damaged area in the frontal lobe known as the medial ventral prefrontal cortex. More recently, that same area figured prominently in a related study published in Nature Neuroscience by Vinod Goel and Raymond Dolan. The researchers took 14 subjects with unimpaired brains and asked them to listen to a series of semantic and phonological jokes. As the subjects listened, their brains were scanned with functional magnetic resonance imaging, which tracked their mental activity. As expected, semantic jokes lit up the brain's posterior temporal lobe, where the semantic network is located; phonological jokes lit up the right temporal lobe, where alternative word meanings are processed. But regardless of the type of joke, the subjects' medial ventral prefrontal cortex always lit up. "If you find the joke funny, the medial ventral prefrontal cortex will activate; if you don't find it funny, it will not activate," Goel says. And the funnier the joke, the greater the activity.

It's tempting to conclude that the search is over, that the seat of all humor has been found. But sometimes a good joke can sneak up on the brain from an unexpected quarter. Take the case of a 16-year-old girl described four years ago in Nature by neurosurgeon Itzhak Fried of the University of California at Los Angeles. Fried was studying the girl's brain to find the source of her epileptic seizures when he noticed a strange pattern: Whenever he administered an electric shock to the patient's left frontal lobe—specifically, to an area less than an inch square—she would start to laugh. If Fried asked her what was so funny, she would blame whatever happened to be in front of her, whether a picture of a horse or the doctors themselves: "You guys are just so funny . . . standing around." When Fried upped the current, the patient's smiles and chuckles grew into guffaws and gales of laughter.

The laughter circuit is built like any good joke, Fried concluded. It has physical, emotional, and cognitive components, any one of which can send the others into hysterics. "We tapped into the network through its motor end," he says. And the medial ventral prefrontal cortex, for all its comedic sophistication, had no choice but to laugh along.


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